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Myocardial Calcium Handling in Type 2 Diabetes: A Novel Therapeutic Target

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posted on 2024-02-06, 10:28 authored by Abhishek Dattani, Anvesha Singh, Gerry P McCann, Gaurav S Gulsin
Type 2 diabetes (T2D) is a multisystem disease with rapidly increasing global prevalence. Heart failure has emerged as a major complication of T2D. Dysregulated myocardial calcium handling is evident in the failing heart and this may be a key driver of cardiomyopathy in T2D, but until recently this has only been demonstrated in animal models. In this review, we describe the physiological concepts behind calcium handling within the cardiomyocyte and the application of novel imaging techniques for the quantification of myocardial calcium uptake. We take an in-depth look at the evidence for the impairment of calcium handling in T2D using pre-clinical models as well as in vivo studies, following which we discuss potential novel therapeutic approaches targeting dysregulated myocardial calcium handling in T2D.

Funding

British Heart Foundation through a Clinical Research Training Fellowship (FS/CRTF/20/24069)

British Heart Foundation through a Clinical Research Training Fellowship (FS/16/47/32190) and Travel Fellowship (FS/TF/21/33008)

Heart failure in type 2 diabetes: improving diagnosis and management in a multi-ethnic population.

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History

Author affiliation

Department of Cardiovascular Sciences, University of Leicester

Version

  • VoR (Version of Record)

Published in

Journal of Cardiovascular Development and Disease

Volume

11

Issue

1

Publisher

MDPI AG

eissn

2308-3425

Copyright date

2023

Available date

2024-02-06

Language

en

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