jcdd-11-00012-v2.pdf (2.39 MB)
Myocardial Calcium Handling in Type 2 Diabetes: A Novel Therapeutic Target
journal contributionposted on 2024-02-06, 10:28 authored by Abhishek Dattani, Anvesha Singh, Gerry P McCann, Gaurav S Gulsin
Type 2 diabetes (T2D) is a multisystem disease with rapidly increasing global prevalence. Heart failure has emerged as a major complication of T2D. Dysregulated myocardial calcium handling is evident in the failing heart and this may be a key driver of cardiomyopathy in T2D, but until recently this has only been demonstrated in animal models. In this review, we describe the physiological concepts behind calcium handling within the cardiomyocyte and the application of novel imaging techniques for the quantification of myocardial calcium uptake. We take an in-depth look at the evidence for the impairment of calcium handling in T2D using pre-clinical models as well as in vivo studies, following which we discuss potential novel therapeutic approaches targeting dysregulated myocardial calcium handling in T2D.
British Heart Foundation through a Clinical Research Training Fellowship (FS/CRTF/20/24069)
British Heart Foundation through a Clinical Research Training Fellowship (FS/16/47/32190) and Travel Fellowship (FS/TF/21/33008)
Heart failure in type 2 diabetes: improving diagnosis and management in a multi-ethnic population.
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NIHR Leicester Biomedical Research Centre and the NIHR Leicester Clinical Research Facility
Author affiliationDepartment of Cardiovascular Sciences, University of Leicester
- VoR (Version of Record)