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Neutron scattering in the biological sciences: progress and prospects.
journal contribution
posted on 2019-09-23, 15:39 authored by R Ashkar, HZ Bilheux, H Bordallo, R Briber, DJE Callaway, X Cheng, XQ Chu, JE Curtis, M Dadmun, P Fenimore, D Fushman, F Gabel, K Gupta, F Herberle, F Heinrich, L Hong, J Katsaras, Z Kelman, E Kharlampieva, GR Kneller, A Kovalevsky, S Krueger, P Langan, R Lieberman, Y Liu, M Losche, E Lyman, Y Mao, J Marino, C Mattos, F Meilleur, P Moody, JD Nickels, WB O'Dell, H O'Neill, U Perez-Salas, J Peters, L Petridis, AP Sokolov, C Stanley, N Wagner, M Weinrich, K Weiss, T Wymore, Y Zhang, JC SmithThe scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018, recent developments in this field are reviewed here, as well as future prospects that can be expected given recent advances in sources, instrumentation and computational power and methods. Crystallography, solution scattering, dynamics, membranes, labeling and imaging are examined. For the extraction of maximum information, the incorporation of judicious specific deuterium labeling, the integration of several types of experiment, and interpretation using high-performance computer simulation models are often found to be particularly powerful.
Funding
The authors thank the National Science Foundation for funding the workshop that led to this article. The workshop was chaired by Jeremy C. Smith and Mark Dadmun. The attendees thank Adam Green and Lora Davis for logistical support. This manuscript has been authored by UT-Battelle LLC under Contract No. DE-AC05-00OR22725 with the US Department of Energy. The United States Government retains and the publisher, by accepting the article for publication, acknowledges that the United States Government retains a non-exclusive, paid-up, irrevocable, worldwide license to publish or reproduce the published form of this manuscript, or allow others to do so, for United States Government purposes. The Department of Energy will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan (http://energy.gov/downloads/ doe-public-access-plan).
History
Citation
Acta Crystallographica. Section d, Structural Biology, 2018, 74 (Pt 12), pp. 1129-1168Author affiliation
/Organisation/COLLEGE OF LIFE SCIENCES/Biological Sciences/Molecular & Cell BiologyVersion
- VoR (Version of Record)
Published in
Acta Crystallographica. Section dPublisher
International Union of Crystallographyeissn
2059-7983Acceptance date
2018-12-12Copyright date
2018Available date
2019-09-23Publisher DOI
Publisher version
http://scripts.iucr.org/cgi-bin/paper?S2059798318017503Language
enAdministrator link
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