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New insights into the role of PML in tumour suppression

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journal contribution
posted on 2008-12-01, 15:34 authored by Paolo Salomoni, Brian J. Ferguson, A. H. Wyllie, Tina Rich
The PML gene is involved in the t(15;17) translocation of acute promyelocytic leukaemia (APL), which generates the oncogenic fusion protein PML-RAR. The PML protein localises to a subnuclear structure called the PML nuclear domain (PML-ND), of which PML is the essential structural component. In APL, PML-NDs are disrupted thus implicating these structures in the pathogenesis of this leukaemia. Unexpectedly, recent studies indicate that PML and the PML-ND play a tumour suppressive role in several different types of human neoplasms in addition to APL. Because of PML’s extreme versatility and involvement in multiple cellular pathways, understanding the mechanisms underlying its function, and therefore role in tumour suppression, have been a challenging task. In this review, we attempt to critically appraise the more recent advances in this field and propose new avenues of investigation.

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Citation

Cell Research, 2008, 18 (6), pp. 622-640

Published in

Cell Research

Publisher

The Nature Publishing Group

issn

1001-0602

Copyright date

1038

Available date

2008-12-01

Publisher version

http://www.nature.com/cr/journal/v18/n6/full/cr200858a.html

Language

en

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