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Nitric Oxide: A Regulator of Cellular Function in Health and Disease

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posted on 2016-11-09, 10:22 authored by L. Sobrevia, L. Ooi, S. Ryan, J. R. Steinert
[First paragraph] Nitric oxide (NO) is a gaseous messenger molecule synthesized from L-arginine and molecular oxygen by three different NO synthases, that is, neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) form [1]. Since its discovery in the early 1980s by the three Nobel Laureates Furchgott, Ignarro & Murad [2], NO has been widely recognised as an important signalling molecule in many physiological processes. The initial identification of NO as an endothelium-derived relaxing factor (EDRF) [3] generated great interest in its function in vascular biology. Over the following years, however, the focus on NO research rapidly expanded from the vascular system to its role in immunity and inflammation, the nervous system, pregnancy, aging, and cell death.

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Citation

Oxidative Medicine and Cellular Longevity, 2016 Article ID 9782346

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Department of Genetics

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  • VoR (Version of Record)

Published in

Oxidative Medicine and Cellular Longevity

Publisher

Hindawi Publishing Corporation

issn

1942-0994;1942-0900

Acceptance date

2015-10-04

Copyright date

2016

Available date

2016-11-09

Publisher version

https://www.hindawi.com/journals/omcl/2016/9782346/

Language

en

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