JOA review submitted.pdf (2.35 MB)
Nociceptin system as a target in sepsis?
journal contribution
posted on 2015-09-03, 10:15 authored by Róisín Thomas, Cordula Stover, David G. Lambert, Jonathan P. ThompsonThe nociceptin system comprises the nociceptin receptor (NOP) and the ligand nociceptin/orphanin FQ (N/OFQ) that binds to the receptor. The archetypal role of the system is in pain processing but the NOP receptor is also expressed on immune cells. Activation of the NOP receptor is known to modulate inflammatory responses, such as mast-cell degranulation, neutrophil rolling, vasodilation, increased vascular permeability, adhesion molecule regulation and leucocyte recruitment. As there is a loss of regulation of inflammatory responses during sepsis, the nociceptin system could be a target for therapies aimed at modulating sepsis. This review details the known effects of NOP activation on leucocytes and the vascular endothelium and discusses the most recent human and animal data on the role of the nociceptin system in sepsis.
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Citation
Journal of Anesthesia, 2014, 28 (5), pp. 759-767Author affiliation
/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and InflammationVersion
- AM (Accepted Manuscript)
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Journal of AnesthesiaPublisher
Springer-Verlag Tokyoissn
0913-8668eissn
1438-8359Acceptance date
2014-03-05Copyright date
2014Available date
2015-10-01Publisher DOI
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http://link.springer.com/article/10.1007/s00540-014-1818-6Language
enAdministrator link
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