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Non-canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

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posted on 2024-02-27, 14:57 authored by Christopher SwitzerChristopher Switzer
DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing. The development of pharmacological agents that modulate the activity of major epigenetic proteins are in pre-clinical development and clinical use. However, recent publications have identified novel redox-based signalling pathways, and therefore novel drug targets, that may exert epigenetic effects. This review will discuss the recent developments in nitric oxide (NO) signalling on DNA methylation as well as potential epigenetic drug targets that have emerged from the intersection of inflammation/redox biology and epigenetic regulation.

History

Citation

Switzer, C. H. (2024). Non-canonicalnitric oxide signalling and DNA methylation: Inflammationinduced epigenetic alterations and potential drug targets.British Journal of Pharmacology,1–16. https://doi.org/10.1111/bph.1630216SWITZER

Author affiliation

Molecular & Cell Biology

Version

  • VoR (Version of Record)

Published in

British Journal of Pharmacology

Publisher

Wiley

issn

0007-1188

eissn

1476-5381

Acceptance date

2023-09-20

Copyright date

2023

Available date

2024-02-27

Spatial coverage

England

Language

eng

Deposited by

Dr Christopher Switzer

Deposit date

2024-02-12

Data Access Statement

N/A-Review.

Rights Retention Statement

  • No

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