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Origins of increased airway smooth muscle mass in asthma

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posted on 2015-07-10, 11:14 authored by Rachid Berair, Ruth Saunders, Christopher E Brightling
Asthma is characterized by both chronic inflammation and airway remodeling. Remodeling--the structural changes seen in asthmatic airways--is pivotal in the pathogenesis of the disease. Although significant advances have been made recently in understanding the different aspects of airway remodeling, the exact biology governing these changes remains poorly understood. There is broad agreement that, in asthma, increased airway smooth muscle mass, in part due to smooth muscle hyperplasia, is a very significant component of airway remodeling. However, significant debate persists on the origins of these airway smooth muscle cells. In this review article we will explore the natural history of airway remodeling in asthma and we will discuss the possible contribution of progenitors, stem cells and epithelial cells in mesenchymal cell changes, namely airway smooth muscle hyperplasia seen in the asthmatic airways.

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Citation

BMC Medicine 2013, 11 : 145

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammation

Version

  • VoR (Version of Record)

Published in

BMC Medicine 2013

Publisher

BioMed Central

eissn

1741-7015

Acceptance date

2013-05-21

Copyright date

2013

Available date

2015-07-10

Publisher version

https://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-11-145

Language

en

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