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Patient acceptability of circulating tumour DNA testing in endometrial cancer follow-up

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journal contribution
posted on 2021-04-16, 11:04 authored by A Relton, A Collins, DS Guttery, DN Gorsia, HJ McDermott, EL Moss
Objective
Circulating tumour DNA (ctDNA) is emerging as a potential option to detect disease recurrence in many cancer types, however, ensuring patient acceptability of changing clinical practice and the introduction of new technology is paramount.

Methods
Patients enrolled in a non‐intervention cohort study determining the ability of ctDNA to detect recurrent endometrial cancer (EC) were invited to participate in a semi‐structured interview. Analysis was performed by Template Analysis.

Results
Eighteen patients were interviewed. A ctDNA blood test was viewed by participants as more physically and psychologically acceptable than clinical examination to monitor for EC recurrence. In particular, participants expressed overwhelming preference for a blood test rather than pelvic examination. Although participants acknowledged that an abnormal ctDNA result could cause anxiety, they expressed a preference to be informed of their results, even if a recurrence was too small to detect radiologically. Explanations for these opinions were a desire for certainty whether their cancer would recur or not, and knowledge would help them be more aware of symptoms that should be reported to their clinician.

Conclusions
ctDNA monitoring to identify EC recurrence appears to be acceptable to patients, and for many, it may be preferable to clinical examination.

Funding

Hope Against Cancer. Grant Number: RM60GO754

Hope Against Cancer/Leicester Precision Medicine Institute in conjunction withUK Department of Health on an Experimental Cancer Medicine Centre. Grant Number: C10604/A25151

Medical Research Council. Grant Number: MCPC17194

History

Author affiliation

Leicester Cancer Research Centre, University of Leicester

Version

  • VoR (Version of Record)

Published in

European Journal of Cancer Care

Pagination

e13429

Publisher

Wiley

issn

0961-5423

eissn

1365-2354

Acceptance date

2021-01-11

Copyright date

2021

Available date

2021-04-16

Spatial coverage

England

Language

English

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