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Xenophontos+et+al+JORC+2019+complete+text+accepted.pdf (811.59 kB)

Peak aerobic capacity from incremental shuttle walk test in chronic kidney disease.

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journal contribution
posted on 2019-08-07, 15:10 authored by S Xenophontos, TJ Wilkinson, DW Gould, EL Watson, JL Viana, AC Smith
BACKGROUND: Assessment of cardiorespiratory fitness is an important outcome in chronic kidney disease (CKD). We aimed to develop a predictive equation to estimate peak oxygen uptake (VO2peak ) and power output (WPeak ), as measured during a cardiopulmonary exercise test (CPET), from the distance walked (DW) during the incremental shuttle walk test (ISWT). METHODS: Thirty-six non-dialysing patients with CKD [17 male, age: 61 ± 12 years, eGFR: 25±7 ml/min/1.73 m2 , body mass index (BMI): 31 ± 6 kg/m2 ] carried out laboratory-based CPET on a cycle ergometer and ISWT on two separate occasions. RESULTS: Linear regression revealed that DW/BMI was a significant predictor of VO2Peak (r = 0.78) (VO2Peak (ml/min/kg) = [0.5688 × (DW/BMI) (m)] + 11.50). No difference (p = 0.66) between CPET VO2Peak (19.9 ± 5.5 ml/min/kg) and predicted VO2Peak (19.9 ± 4.3 ml/min/kg) was observed. DW multiplied by body mass (BM) was a significant predictor of WPeak (r = 0.80) [WPeak (W) = (0.0018 × (DW × BM)) + 50.47]. No difference (p = 0.97) between CPET WPeak (116.2 ± 38.9 W) and estimated WPeak (113.9 ± 30.1 W) was seen. CONCLUSION: The present study demonstrates that VO2Peak and WPeak can be accurately estimated using the DW during an ISWT in CKD populations.


This research was co‐funded by the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre (BRC) and the Stoneygate Trust. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, NIHR Leicester BRC or the Department of Health. At the time of writing this manuscript, E.L.W. was supported by a Kidney Research UK Post‐Doctoral Fellowship (PDF2–2015).



Journal of Renal Care, 2019

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/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Infection, Immunity and Inflammation


  • AM (Accepted Manuscript)

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Journal of Renal Care


Wiley for European Dialysis and Transplant Nurses Association, European Renal Care Association



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