Physical activity and metabolic health: Is it all in the timing?

<p dir="ltr">Regular physical activity is a cornerstone treatment for the prevention and management of multiple chronic diseases, including type 2 diabetes (T2DM) and obesity [<a href="https://www.nature.com/articles/s41366-025-01736-2#ref-CR1" target="_blank">1</a>]. It elicits a myriad of physiological benefits across the life course, including favourable effects on body composition and markers of glycaemic control. That said, its application is often based on a one-size-fits-all approach, and there is considerable variability in how individuals respond. [Opening paragraph]</p>