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Plasma desmosine for prediction of outcomes after acute myocardial infarction

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posted on 2023-07-25, 15:16 authored by Kashan Ali, Muhammad Zubair Israr, Leong L Ng, Ify Mordi, Chim C Lang, Elena Kuzmanova, Jeffrey T-J Huang, Anna-Maria Choy

Elastin degradation is implicated in the pathology of vulnerable plaque. Recent studies show promising results for plasma desmosine (pDES), an elastin-specific degradation product, as a marker of cardiovascular disease (CVD) outcomes. The aim of this study was to investigate the potential role of pDES as a marker of clinical outcome in patients with acute myocardial infarction (AMI).In this case-control study, we studied 236 AMI patients: 79 patients who had death and/or myocardial infarction (MI) at 2 years, and 157 patients who did not have an event at 2 years. pDES was measured using a validated liquid chromatography-tandem mass spectrometry method. Association of pDES with adverse outcomes, and the incremental value of pDES to global registry of acute coronary events (GRACE) score for risk stratification was assessed.pDES levels were elevated in patients with the composite outcome of death/MI at 2 years (p = 0.002). Logistic regression analyses showed pDES to be associated with death/MI at 2 years [Odds ratio (OR) 5.99 (95% CI 1.81-19.86) p = 0.003]. pDES remained a significant predictor of death/MI at 2 years even after adjustment for age, sex, history of CVD, revascularisation, blood pressure, medications on discharge, Troponin I, and NT-proBNP levels.[OR 5.60 (95% CI 1.04-30.04) p = 0.044]. In another multivariable model including adjustment for eGFR, pDES was significantly associated with the composite outcome at 6 months, but not at 2 years follow up. DES was also able to reclassify risk stratification for death/MI at 6 months, when added to the GRACE risk model [Net Reclassification Index (NRI) 41.2 (95% CI 12.0-70.4) p = 0.006].pDES concentrations predict clinical outcomes in patients with AMI, demonstrating its potential role as a prognostic marker in AMI.

Funding

This study was supported by the departmental funds at the University of Dundee.

History

Citation

Ali, Kashan, Muhammad Zubair Israr, Leong L. Ng, Ify Mordi, Chim C. Lang, Elena Kuzmanova, Jeffrey TJ Huang, and Anna-Maria Choy. "Plasma desmosine for prediction of outcomes after acute myocardial infarction." Frontiers in Cardiovascular Medicine 9 (2022): 992388.

Author affiliation

Department of Cardiovascular Sciences

Version

  • VoR (Version of Record)

Published in

Frontiers in cardiovascular medicine

Volume

9

Pagination

992388

Publisher

Frontiers Media SA

issn

2297-055X

eissn

2297-055X

Acceptance date

2022-10-18

Copyright date

2022

Available date

2023-07-25

Spatial coverage

Switzerland

Language

eng

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