University of Leicester
Pooling data from different populations: should there be regional differences in cerebral haemodynamics?.pdf (597.35 kB)

Pooling data from different populations: should there be regional differences in cerebral haemodynamics?

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posted on 2019-09-24, 13:12 authored by ASM Salinet, RB Panerai, J Caldas, RC Nogueira, AB Conforto, MJ Texeira, E Bor-Seng-Shu, TG Robinson
BACKGROUND: Though genetic and environmental determinants of systemic haemodynamic have been reported, surprisingly little is known about their influences on cerebral haemodynamics. We assessed the potential geographical effect on cerebral haemodynamics by comparing the individual differences in cerebral blood flow velocity (CBFv), vasomotor tone (critical closing pressure- CrCP), vascular bed resistance (resistance-area product- RAP) and cerebral autoregulation (CA) mechanism on healthy subjects and acute ischaemic stroke (AIS) patients from two countries. METHODS: Participants were pooled from databases in Leicester, United Kingdom (LEI) and São Paulo, Brazil (SP) research centres. Stroke patients admitted within 48 h of ischaemic stroke onset, as well as age- and sex-matched controls were enrolled. Beat-to-beat blood pressure (BP) and bilateral mean CBFv were recorded during 5 min baseline. CrCP and RAP were calculated. CA was quantified using transfer function analysis (TFA) of spontaneous oscillations in arterial BP and mean CBFv, and the derived autoregulatory index (ARI). RESULTS: A total of 100 participants (50 LEI and 50 SP) were recruited. No geographical differences were found. Both LEI and SP AIS participants showed lower values of CA compared to controls. Moreover, the affected hemisphere presented lower resting CBFv and higher RAP compared to the unaffected hemisphere in both populations. CONCLUSIONS: Impairments of cerebral haemodynamics, demonstrated by several key parameters, was observed following AIS compared to controls irrespective of geographical region. These initial results should encourage further research on cerebral haemodynamic research with larger cohorts combining different populations.


The work was supported by the Brazilian Ministry of Education (Grant number 0411-10-8) and São Paulo Research Foundation (Grant number 2014/04955–8).



BMC Neurology, 2018, 18, Article number: 156

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The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.