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Pregabalin-induced first degree atrioventricular block in a young patient treated for pain from extrapulmonary tuberculosis

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posted on 2019-08-23, 14:48 authored by A Schiavo, FM Stagnaro, A Salzano, AM Marra, E Bobbio, P Valente, S Grassi, M Miniero, M Arcopinto, M Matarazzo, R Napoli, A Cittadini
Pregabalin, widely used in the treatment of several pain disorders, is usually well tolerated. Uncommonly, the drug may induce cardiac side effects, rarely prolongation of the PR interval. The latter has never been described in patients with healthy heart or normal renal function. We characterize a unique case of a young man with extrapulmonary tuberculosis and no detectable or known cardiac or kidney diseases, treated with pregabalin to control the severe pain due to the involvement of the spinal cord by the tuberculosis, showing an atrioventricular (AV) block due to pregabalin administration. The reported case emphasizes the need of monitoring PR interval during treatment with pregabalin, even in patients without background of cardiac or renal diseases.

History

Citation

Monaldi Archives for Chest Disease, 2017, 87 (3)

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Cardiovascular Sciences

Version

  • VoR (Version of Record)

Published in

Monaldi Archives for Chest Disease

Publisher

Page Press

issn

1122-0643

eissn

2465-1028

Acceptance date

2017-09-20

Copyright date

2017

Available date

2019-08-23

Language

en

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