ALSPAC_BLUE_Air pollution_lung function.pdf (1.49 MB)
Prenatal, Early-life and Childhood Exposure to Air Pollution and Lung Function: The ALSPAC Cohort.
journal contributionposted on 2020-04-02, 13:35 authored by Yutong Cai, Anna L Hansell, Raquel Granell, Marta Blangiardo, Mariagrazia Zottoli, Daniela Fecht, John Gulliver, A John Henderson, Paul Elliott
RATIONALE:Exposure to air pollution during intrauterine development and through childhood may have lasting effects on respiratory health. OBJECTIVES:To investigate lung function at ages 8 and 15 years in relation to air pollution exposures during pregnancy, infancy and childhood in a UK population-based birth cohort. METHODS:Individual exposures to source-specific particulate matter with diameter ≤10µm (PM10) during each trimester, 0-6 months, 7-12 months (1990-1993) and up to age 15 years (1991-2008) were examined in relation to %predicted Forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) at ages 8(N=5,276) and 15(N=3,446) years, usinglinear regression models adjusted for potential confounders. A profile regression model was used to identify sensitive time periods. MEASUREMENTS AND MAIN RESULTS:We did not find clear evidence for a sensitive exposure period for PM10 from road-traffic: at age 8 years, 1µg/m3 higher exposure during the first trimester was associated with lower %predicted of FEV1(-0.826, 95%CI:-1.357 to -0.296) and FVC(-0.817, 95%CI:-1.357 to -0.276), but similar associations were seen for exposures for other trimesters, 0-6 months, 7-12 months, and 0-7 years. Associations were stronger among boys, children whose mother had a lower education level or smoked during pregnancy. For PM10 from all sources, the third trimester was associated with lower %predicted of FVC (-1.312, 95%CI: -2.100 to -0.525). At age 15 years, no adverse associations were seen with lung function. CONCLUSIONS:Exposure to road-traffic PM10 during pregnancy may result in small but significant reductions in lung function at age 8 years.
This research was funded by the UK Medical Research Council (grant number: G0700920). The UK Medical Research Council and Wellcome (grant number: 102215/2/13/2) and the University of Bristol provide core support for ALSPAC. The Medical Research Council Centre for Environment and Health is funded by the UK Medical Research Council (grant number MR/S019669/1). Y.C. was supported by a MRC Early-Career Research Fellowship awarded through the MRC Centre for Environment and Health (grant number MR/M501669/1). P.E. acknowledges funding from the National institute for Health Research (NIHR) Imperial Biomedical Research Centre, the NIHR Health Protection Research Unit in Health Impact of Environmental Hazards (HPRU-2012-10141) and the UK Dementia Research Institute supported by UK DRI Ltd which is funded by the UK Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK. P.E. is associate director of Health Data Research UK-London which receives funding from a consortium led by the UK Medical Research Council.
CitationAmerican Journal of Respiratory and Critical Care Medicine, 2020, in press
Author affiliationCentre for Environmental Health and Sustainability
- AM (Accepted Manuscript)