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Proportion of Idiopathic Pulmonary Fibrosis Risk Explained by Known Common Genetic Loci in European Populations

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journal contribution
posted on 2022-07-05, 08:20 authored by OC Leavy, SF Ma, PL Molyneaux, TM Maher, JM Oldham, C Flores, I Noth, R Gisli Jenkins, F Dudbridge, LV Wain, RJ Allen

Understanding how genetic factors contribute to disease risk improves our understanding of pathogenesis, supports drug development, and aids risk prediction (1). Appropriate quantification and interpretation of this contribution is essential for measuring the impact of genetic variation and in motivating and informing future studies. 

Funding

R.J.A. is an Action for Pulmonary Fibrosis Research Fellow. L.V.W. holds a GlaxoSmithKline/British Lung Foundation Chair in Respiratory Research (C17-1). R.G.J. is supported by a National Institute for Health Research (NIHR) Research Professorship (NIHR reference RP-2017-08-ST2-014). I.N. is supported by NHLBI grant R01HL130796. C.F. is supported by the Spanish Ministry of Science and Innovation (grant RTC-2017-6471-1; Agencia Estatal de Investigaci ´on/Fondo Europeo de Desarrollo Regional, UE), cofinanced by the European Regional Development Funds “A way of making Europe” from the European Union, and by the agreement OA17/008 with Instituto Tecnol ´ogico y de Energ´ıas Renovables to strengthen scientific and technological education, training, research, development, and innovation in Genomics, Personalized Medicine, and Biotechnology. P.L.M. is an Action for Pulmonary Fibrosis Research Fellow. T.M.M. is supported by an NIHR Clinician Scientist Fellowship (NIHR Ref: CS-2013-13-017) and a British Lung Foundation Chair in Respiratory Research (C17-3). J.M.O. is supported by NHLBI grant K23HL138190.

History

Citation

American Journal of Respiratory and Critical Care Medicine, 203 (6), pp. 775-778https://doi.org/10.1164/rccm.202008-3211LE

Author affiliation

Department of Health Sciences, University of Leicester

Version

  • VoR (Version of Record)

Published in

American Journal of Respiratory and Critical Care Medicine

Volume

203

Issue

6

Pagination

775 - 778

Publisher

American Thoracic Society

issn

1073-449X

eissn

1535-4970

Acceptance date

2020-11-23

Copyright date

2020

Available date

2022-07-05

Spatial coverage

United States

Language

English

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