Prospectively Reallocating Sedentary Time: Associations with Cardiometabolic Health.

PURPOSE:To investigate whether prospectively reallocating time away from sedentary behaviour into different physical activity intensities is associated with 12-month change to cardiometabolic health in a cohort at high risk of type 2 diabetes (T2DM). METHODS:Participants with known risk factors for T2DM were recruited from primary care (Leicestershire, UK) as part of the Walking Away from Type 2 Diabetes trial (n=808). Participants were followed-up at 12, 24 and 36 months. Sedentary behaviour (SB), light-intensity physical activity (LPA) and moderate-to-vigorous intensity physical activity (MVPA) were measured objectively by accelerometer. Post-challenge glucose, triglycerides, HDL-cholesterol, systolic blood pressure and waist circumference were analysed individually and combined into a clustered cardiometabolic risk score (CMRS). Associations of changing SB over each consecutive 12-month period were analysed taking account of repeated measures.