ProgBMB2016celldivisiondrev5.pdf (730.65 kB)
Quantum counting: Operator methods for discrete population dynamics with applications to cell division
journal contributionposted on 2017-07-06, 15:29 authored by T. R. Robinson, E. Haven, A. M. Fry
The set of natural numbers may be identified with the spectrum of eigenvalues of an operator (quantum counting), and the dynamical equations of populations of discrete, countable items may be formulated using operator methods. These equations take the form of time dependent operator equations, involving Hamiltonian operators, from which the statistical time dependence of population numbers may be determined. The quantum operator method is illustrated by a novel approach to cell population dynamics. This involves Hamiltonians that mimic the process of stimulated cell division. We evaluate two different models, one in which the stimuli are expended in the division process and one in which the stimuli act as true catalysts. While the former model exhibits only bounded cell population variations, the latter exhibits two distinct regimes; one has bounded population fluctuations about a mean level and in the other, the population can undergo growth to levels that are orders of magnitude above threshold levels, through an instability that could be interpreted as a cancerous growth phase.
AMF is funded by Worldwide Cancer Research.
CitationProgress in Biophysics and Molecular Biology, 2017
Author affiliation/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Physics and Astronomy
- AM (Accepted Manuscript)