Radiotherapy induced senescence and its effect on response to treatment_REVISED.pdf (404.82 kB)
Radiotherapy-Induced Senescence and its Effects on Responses to Treatment.
journal contributionposted on 2019-06-06, 14:09 authored by A. F. S. Tabasso, D. J. L. Jones, G. D. D. Jones, S. Macip
Radiotherapy is still a treatment of choice for many malignancies, often in combination with other strategies. However, its efficacy is limited by the dose that can be safely administered without eliciting serious side-effects, as well as the fact that recurrence is common, particularly in large tumours. Combining radiotherapy with drugs that could sensitise cells to radiation and/or reduce the factors that promote the recovery of the surviving cancer cells is a promising approach. Ionising radiation has been shown to induce senescence and the accumulation of senescent cells creates a microenvironment that facilitates neoplastic growth. This provides a rationale to test the addition of anti-senescent drugs, some of which are already available in the clinic, to radiotherapy protocols. Here, we discuss the relevance of radiotherapy-induced senescent cell accumulation and the potential interventions to minimise its negative effects.
This work was partially supported by the M.C. Andreu Memorial Fund.
CitationClinical Oncology, 2019, 31 (5), pp. 283-289
Author affiliation/Organisation/COLLEGE OF LIFE SCIENCES/Biological Sciences/Molecular & Cell Biology
- AM (Accepted Manuscript)