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Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2).

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posted on 2012-10-24, 08:55 authored by A. D. Barlow, J. Xie, C. E. Moore, S. C. Campbell, J. A. Shaw, M. L. Nicholson, T. P. Herbert
Rapamycin (sirolimus) is one of the primary immunosuppressants for islet transplantation. Yet there is evidence that the long-term treatment of islet-transplant patients with rapamycin may be responsible for subsequent loss of islet graft function and viability. Therefore, the primary objective of this study was to elucidate the molecular mechanism of rapamycin toxicity in beta cells.

History

Citation

Diabetologia, 2012, 55 (5), pp. 1355-1365

Published in

Diabetologia

Publisher

Springer Verlag (Germany)

issn

0012-186X

eissn

1432-0428

Acceptance date

2012-01-09

Copyright date

2012

Available date

2012-10-24

Publisher version

http://link.springer.com/article/10.1007/s00125-012-2475-7

Notes

The online version of this article (doi:10.1007/s00125-012-2475-7) contains peer-reviewed but unedited supplementary material, which is available to authorised users.

Language

eng