Rationale and design of the United Kingdom Heart Failure with Preserved Ejection Fraction Registry
Objective: Heart failure with preserved ejection fraction (HFpEF) is a common heterogeneous syndrome that remains imprecisely defined and consequently has limited treatment options and poor outcomes. Methods: The UK Heart Failure with Preserved Ejection Fraction Registry (UK HFpEF) is a prospective data-enabled cohort and platform study. The study will develop a large, highly characterised cohort of patients with HFpEF. A biobank will be established. Deep clinical phenotyping, imaging, multiomics and centrally held national electronic health record data will be integrated at scale, in order to reclassify HFpEF into distinct subgroups, improve understanding of disease mechanisms and identify new biological pathways and molecular targets. Together, these will form the basis for developing diagnostics and targeted therapeutics specific to subgroups. It will be a platform for more effective and efficient trials, focusing on subgroups in whom targeted interventions are expected to be effective, with consent in place to facilitate rapid recruitment, and linkage for follow-up. Patients with a diagnosis of HFpEF made by a heart failure specialist, who have had natriuretic peptide levels measured and a left ventricular ejection fraction >40% are eligible. Patients with an ejection fraction between 40% and 49% will be limited to no more than 25% of the cohort. Conclusions: UK HFpEF will develop a rich, multimodal data resource to enable the identification of disease endotypes and develop more effective diagnostic strategies, precise risk stratification and targeted therapeutics. Trial registration number: NCT05441839.
History
Author affiliation
College of Life Sciences/Cardiovascular SciencesVersion
- VoR (Version of Record)
Published in
HeartVolume
110Pagination
359-365Publisher
BMJissn
1355-6037eissn
1468-201XCopyright date
2023Available date
2024-03-11Publisher DOI
Spatial coverage
EnglandLanguage
engPublisher version
Deposited by
Professor Iain SquireDeposit date
2024-02-12Data Access Statement
Data sharing not applicable as no data sets generated and/or analysed for this study. No data were analysed or available for this registry protocol manuscript.Rights Retention Statement
- No