Real-time monitoring of exhaled volatiles using atmospheric pressure chemical ionization on a compact mass spectrometer
journal contributionposted on 2016-07-15, 10:01 authored by Liam M. Heaney, Dorota M. Ruszkiewicz, Kayleigh L. Arthur, Andria Hadjithekli, Clive Aldcroft, Martin R. Lindley, C. L. Paul Thomas, Matthew A. Turner, James C. Reynolds
AIM: Breath analyses have potential to detect early signs of disease onset. Ambient ionization allows direct combination of breath gases with MS for fast, on-line analysis. Portable MS systems would facilitate field/clinic-based breath analyses. Results & methodology: Volunteers ingested peppermint oil capsules and exhaled volatile compounds were monitored over 10 h using a compact mass spectrometer. A rise and fall in exhaled menthone was observed, peaking at 60-120 min. Real-time analysis showed a gradual rise in exhaled menthone postingestion. Sensitivity was comparable to established methods, with detection in the parts per trillion range. CONCLUSION: Breath volatiles were readily analyzed on a portable mass spectrometer through a simple inlet modification. Induced changes in exhaled profiles were detectable with high sensitivity and measurable in real-time.
CitationBioanalysis, 2016, 8 (13), pp. 1325-1336
Author affiliation/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciences
- AM (Accepted Manuscript)