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Recent Advances in Catalysis Using Organoborane-Mediated Hydride Abstraction

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journal contribution
posted on 2023-11-06, 11:20 authored by JP Gillions, SA Elsherbeni, L Winfrey, L Yun, RL Melen, LC Morrill, AP Pulis

C-H functionalization is widely regarded as an important area in the development of synthetic methodology, enabling the design of more time- and atom-efficient syntheses. The ability of electron-deficient organoboranes to mediate hydride abstraction from α-amino C?H bonds is therefore of great interest, as the reactive iminium and hydridoborate moieties generated are able to participate in a range of synthetically useful transformations. In this review update, we cover the recent advances made in organoborane mediated hydride abstraction, with particular focus on the catalytic applications of electron deficient boranes for α- or β- functionalization, α,β-difunctionalization, and the dehydrogenation of amines.

Funding

Stopped-Flow NMR Spectroscopy for the Physical and Life Sciences

Engineering and Physical Sciences Research Council

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Engineering and Physical Sciences Research Council (EPSRC) EP/Y00146X/1

History

Author affiliation

School of Chemistry, University of Leicester

Version

  • VoR (Version of Record)

Published in

Synlett

Volume

34

Issue

18

Pagination

2117-2128

Publisher

Georg Thieme Verlag KG

issn

0936-5214

eissn

1437-2096

Copyright date

2023

Available date

2023-11-06

Language

en

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