Recommendations for Design, Execution, and Reporting of Studies on Experimental Thoracic Aortopathy in Preclinical Models

<p dir="ltr">There is a recent dramatic increase in research on thoracic aortic diseases that<br>includes aneurysms, dissections, and rupture. Experimental studies predominantly use<br>mice in which aortopathy is induced by chemical interventions, genetic manipulations, or<br>both. Many parameters should be deliberated in experimental design in concert with<br>multiple considerations when providing dimensional data and characterization of aortic<br>tissues. The purpose of this review is to provide recommendations on guidance in: (1)<br>selection of mouse model and experimental conditions for the study, (2) parameters for<br>standardizing detection and measurements of aortic diseases, (3) meaningful<br>interpretation of characteristics of diseased aortic tissue, and (4) reporting standards<br>that include rigor and transparency.</p>