10.1039_b418039a.pdf (351.5 kB)
Recycling of a perfluoroalkylated BINOL ligand using fluorous solid-phase extraction.
journal contributionposted on 2009-12-08, 16:23 authored by John Fawcett, Eric G. Hope, Alison M. Stuart, Andrew J. West
After the asymmetric addition of allyltri-n-butyltin to benzaldehyde, a perfluoroalkylated BINOL-Sn complex was separated from the organic product using fluorous reverse phase silica gel. The lightly fluorinated ligand was then recovered by hydrolysis of the R[subscript f6]-BINOL-Sn complex with dilute hydrochloric acid and was reused three times without loss of activity or enantioselectivity.
CitationGreen Chemistry, 2005, 7 (5), pp.316-320
- VoR (Version of Record)