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Reducing excess mortality due to chronic disease in people with severe mental illness: meta-review of health interventions.

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posted on 2017-08-24, 10:28 authored by Amanda J. Baxter, Meredith G. Harris, Yasmin Khatib, Traolach S. Brugha, Heidrun Bien, Kamaldeep Bhui
BACKGROUND: People with severe mental illness (SMI) have high rates of chronic disease and premature death. AIMS: To explore the strength of evidence for interventions to reduce risk of mortality in people with SMI. METHOD: In a meta-review of 16 systematic reviews of controlled studies, mortality was the primary outcome (8 reviews). Physiological health measures (body mass index, weight, glucose levels, lipid profiles and blood pressure) were secondary outcomes (14 reviews). RESULTS: Antipsychotic and antidepressant medications had some protective effect on mortality, subject to treatment adherence. Integrative community care programmes may reduce physical morbidity and excess deaths, but the effective ingredients are unknown. Interventions to improve unhealthy lifestyles and risky behaviours can improve risk factor profiles, but longer follow-up is needed. Preventive interventions and improved medical care for comorbid chronic disease may reduce excess mortality, but data are lacking. CONCLUSIONS: Improved adherence to pharmacological and physical health management guidelines is indicated.

History

Citation

The British Journal of Psychiatry, 2016, 208 (4), pp. 322-329

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Health Sciences

Version

  • AM (Accepted Manuscript)

Published in

The British Journal of Psychiatry

Publisher

Royal College of Psychiatrists

issn

0007-1250

eissn

1472-1465

Acceptance date

2016-09-21

Copyright date

2016

Available date

2017-08-24

Publisher version

http://bjp.rcpsych.org/content/208/4/322

Language

en

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