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CVR 2018 125 R1 Accepted Version.pdf (75.83 kB)

Reperfusion in the brain: is time important? The DAWN and DEFUSE-3 trials.

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journal contribution
posted on 2018-04-23, 14:27 authored by Thompson Robinson
(Opening paragraph) Reperfusion therapy using intravenous thrombolysis and mechanical thrombectomy are the only approved treatments for acute ischaemic stroke, but must be administered in a narrow therapeutic window of up to 4.5 and 6 h, respectively. A further meta-analysis by the HERMES (Highly Effective Reperfusion evaluated in Multiple Endovascular Stroke Trials) collaboration has suggested that mechanical thrombectomy may be beneficial up to 7.3 h after stroke onset. However, the results of the DAWN (DWI or CTP Assessment with Clinical Mismatch in the Triage of Wake-Up and Late Presenting Strokes Undergoing Neurointervention with Trevo) and the DEFUSE 3 (Endovascular Therapy Following Imaging Evaluation for Ischaemic Stroke)7 trials may extend this window up to 24 h in carefully selected patients.

History

Citation

Cardiovascular Research , 2018, Volume 114, Issue 5, pp. e28–e29

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Cardiovascular Sciences

Version

  • AM (Accepted Manuscript)

Published in

Cardiovascular Research

Publisher

Oxford University Press

issn

0008-6363

eissn

1755-3245

Copyright date

2018

Available date

2019-03-24

Publisher version

https://academic.oup.com/cardiovascres/article/114/5/e28/4953548

Notes

The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en

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