Reply to Maleszka et al.: DNA methylation signals persist across insect metamorphosis.

<p dir="ltr">Previously (1), we demonstrated that the wasp, Nasonia vitripennis, responds to larval diapause with an extended adult lifespan and a slowing of epigenetic aging. We proposed Nasonia as a tractable model for dissecting the causal mechanisms of epigenetic aging. Maleszka et al. (2) raise concerns regarding specific analytical procedures and the biological plausibility of DNA methylation signals persisting across insect metamorphosis.</p>