Reply to Mekary, R.A.; Ding, E.L. Isotemporal Substitution as the Gold Standard Model for Physical Activity Epidemiology: Why It Is the Most Appropriate for Activity Time Research. Int. J. Environ. Res. Public Health 2019, 16, 797.

Firstly, we would like to thank the authors for taking the time to review and comment on our paper. We believe it is invaluable to have open debates regarding current methodologies and the inference of research outputs. In the spirit of open debate and constructive discussion, we wish to respond to the observations of Mekary and Ding.