Ring expansion and chain extension of alkyl amines

<p dir="ltr">Amines are highly valued molecules, used to understand biological processes and in the discovery of new medicines. However, medium-sized cyclic and macrocyclic amines are extremely challenging to synthesize and are therefore underutilized. Now, up to 15-membered cyclic amines can be formed directly from smaller, more accessible rings via an organoborane-catalysed two-carbon-unit C–C bond insertion.</p>