Risk of lower extremity amputation in patients with type 2 diabetes mellitus and peripheral arterial disease receiving sodium‐glucose cotransporter‐2 inhibitors versus other medications: A systematic review and meta‐analysis of observational cohort studies

Type 2 diabetes mellitus (T2DM) is associated with significant microvascular and macrovascular complications, leading to an increased risk of morbidity and mortality. Advancement in the treatment of T2DM has led to the development of novel therapies, such as sodium-glucose cotransporter 2 (SGLT2) inhibitors, which have been shown to significantly reduce adverse health outcomes. [Opening paragraph]