Role of intestinal microecology in the regulation of energy metabolism by dietary polyphenols and their metabolites.
journal contributionposted on 2019-06-14, 12:58 authored by S Lin, Z Wang, K-L Lam, S Zeng, BK Tan, J Hu
Background: Polyphenols are a class of plant secondary metabolites with a variety of physiological functions. Polyphenols and their intestinal metabolites could greatly affect host energy metabolism via multiple mechanisms. Objective: The objective of this review was to elaborate the role of intestinal microecology in the regulatory effects of dietary polyphenols and their metabolites on energy metabolism. Methods: In this review, we illustrated the potential mechanisms of energy metabolism regulated by the crosstalk between polyphenols and intestinal microecology including intestinal microbiota, intestinal epithelial cells, and mucosal immune system. Results: Polyphenols can selectively regulate the growth of susceptible microorganisms (eg. reducing the ratio of Firmicutes to Bacteroides, promoting the growth of beneficial bacteria and inhibiting pathogenic bacteria) as well as alter bacterial enzyme activity. Moreover, polyphenols can influence the absorption and secretion of intestinal epithelial cells, and alter the intestinal mucosal immune system. Conclusion: The intestinal microecology play a crucial role for the regulation of energy metabolism by dietary polyphenols.
The authors are grateful to the National Natural Science Foundation of China (81703065), Natural Science Foundation of Fujian Province (2016J05067), Research Fund for Taiwan-Straits Postdoctoral Exchange Program (2018B003), and the China Postdoctoral Science Foundation (2018M63072) for financial support.
CitationFood and Nutrition Research, 2019, 63: 1518
Author affiliation/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Department of Cardiovascular Sciences
- VoR (Version of Record)