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SecReT4: a web-based bacterial type IV secretion system resource..pdf (4.8 MB)

SecReT4: a web-based bacterial type IV secretion system resource

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posted on 2015-07-21, 08:22 authored by D. Bi, L. Liu, C. Tai, Z. Deng, Kumar Rajakumar, H. Y. Ou
SecReT4 (http://db-mml.sjtu.edu.cn/SecReT4/) is an integrated database providing comprehensive information of type IV secretion systems (T4SSs) in bacteria. T4SSs are versatile assemblages that promote genetic exchange and/or effector translocation with consequent impacts on pathogenesis and genome plasticity. T4SSs have been implicated in conjugation, DNA uptake and release and effector translocation. The effectors injected into eukaryotic target cells can lead to alteration of host cellular processes during infection. SecReT4 offers a unique, highly organized, readily exploreable archive of known and putative T4SSs and cognate effectors in bacteria. It currently contains details of 10 752 core components mapping to 808 T4SSs and 1884 T4SS effectors found in representatives of 289 bacterial species, as well as a collection of more than 900 directly related references. A broad range of similarity search, sequence alignment, phylogenetic, primer design and other functional analysis tools are readily accessible via SecReT4. We propose that SecReT4 will facilitate efficient investigation of large numbers of these systems, recognition of diverse patterns of sequence-, gene- and/or functional conservation and an improved understanding of the biological roles and significance of these versatile molecular machines. SecReT4 will be regularly updated to ensure its ongoing maximum utility to the research community.

History

Citation

Nucleic Acids Res, 2013, 41 (Database issue), pp. D660-D665

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammation

Version

  • VoR (Version of Record)

Published in

Nucleic Acids Res

Publisher

Oxford University Press

issn

0305-1048

eissn

1362-4962

Acceptance date

2012-11-04

Copyright date

2012

Available date

2015-07-21

Publisher version

http://nar.oxfordjournals.org/content/41/D1/D660

Language

en

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