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Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad

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posted on 2010-09-14, 14:55 authored by Kah Wai Lim, Patrizia Alberti, Aurore Guédin, Laurent Lacroix, Jean-François Riou, Nicola J. Royle, Jean-Louis Mergny, Anh Tuân Phan
Short contiguous arrays of variant CTAGGG repeats in the human telomere are unstable in the male germline and somatic cells, suggesting formation of unusual structures by this repeat type. Here, we report on the structure of an intramolecular G-quadruplex formed by DNA sequences containing four human telomeric variant CTAGGG repeats in potassium solution. Our results reveal a new robust antiparallel G-quadruplex fold involving two G-tetrads sandwiched between a G·C base pair and a G·C·G·C tetrad, which could represent a new platform for drug design targeted to human telomeric DNA.

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Citation

Nucleic Acids Research, 2009, 37 (18), pp. 6239-6248.

Published in

Nucleic Acids Research

Publisher

Oxford University Press (OUP)

issn

0305-1048

Copyright date

2009

Available date

2010-09-14

Publisher version

http://nar.oxfordjournals.org/content/37/18/6239

Language

en

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