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Serum Albumin and Future Risk of Hip, Humeral, and Wrist Fractures in Caucasian Men: New Findings from a Prospective Cohort Study

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posted on 2019-06-03, 13:20 authored by S. K. Kunutsor, A. Voutilainen, M. R. Whitehouse, S. Seidu, J. Kauhanen, A. W. Blom, J. A. Laukkanen
Logo Medical Principles and Practice Download Fulltext PDF Original Paper Open Access Gateway Serum Albumin and Future Risk of Hip, Humeral, and Wrist Fractures in Caucasian Men: New Findings from a Prospective Cohort Study Kunutsor S.K.a,b · Voutilainen A.c · Whitehouse M.R.a,b · Seidu S.d,e · Kauhanen J.c · Blom A.W.a,b · Laukkanen J.A.c,f,g Author affiliations Corresponding Author Keywords: Serum albuminFracture Med Princ Pract Abstract FullText PDF References Extras : 5 S. Karger AG Go to Top Abstract Recommend this FullText PDF Abstract Objective: Low serum albumin concentration is associated with poor health outcomes, but its relationship with the risk of fractures has not been reliably quantified. We aimed to assess the prospective association of serum albumin with the risk of fractures in a general population. Subjects and Methods: Baseline serum albumin concentrations were measured in 2,245 men aged 42–61 years in the Kuopio Is­chemic Heart Disease study. Hazard ratios (HRs) (95% confidence intervals) were calculated for incident fractures. Results: A total of 121 fractures (hip, humeral, or wrist) were recorded during a median follow-up of 25.6 years. The risk of fractures increased linearly below a serum albumin concentration of ∼48 g/L. The age-adjusted HR (95% CI) for fractures per 1 standard deviation lower serum albumin was 1.24 (1.05–1.48). On further adjustment for several conventional and emerging risk factors, the HR was attenuated to 1.21 (1.01–1.45). Comparing the bottom versus top quartile of serum albumin levels, the corresponding adjusted HRs were 2.48 (1.37–4.48) and 2.26 (1.23–4.14). The association of serum albumin with fracture risk did not differ substantially according to age, body mass index, blood pressure, physical activity, alcohol consumption, socioeconomic status, inflammation, prevalent diseases, and smoking. Serum albumin at a threshold of 41.5 g/L demonstrated an area under the curve of 0.5850. Conclusion: In middle-aged Caucasian men, low serum albumin is associated with an increased risk of future fractures. The potential relevance of serum albumin concentrations in fracture prevention and prediction deserves further evaluation.


We thank the staff of the Kuopio Research Institute of Exercise Medicine and the Research Institute of Public Health and University of Eastern Finland, Kuopio, Finland, for collecting data. This work was supported by the Finnish Foundation for Cardiovascular Research, Helsinki, Finland. Drs. Kunutsor, Whitehouse, and Blom acknowledge support from the NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol.



Medical Principles and Practice, 2019

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