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Serum potassium and glucose regulation in the ADDITION- Leicester screening study
journal contributionposted on 2015-03-31, 09:24 authored by Patrice Carter, Danielle H. Bodicoat, L. M. Quinn, Francesco Zaccardi, David Webb, Kamlesh Khunti, Melanie J. Davies
Introduction: Previous observational studies have shown conflicting results between plasma K+ concentrations and risk of type 2 diabetes. To help clarify the evidence we aimed to determine whether an association existed between serum K+ and glucose regulation within a UK multi ethnic population Methods: Participants were recruited as part of the ADDITION Leicester study, a population based screening study. Individuals from primary care between the age of 40-75 years if White European or 25-75 years if South Asian or Afro Caribbean were recruited. Tests for associations between baseline characteristics and K+ quartiles were conducted using linear regression models. Results: Data showed individuals in the lowest K+ quartile had significantly greater 2-hour glucose levels (0.53mmol/l, 95% CI: 0.36-0.70, p≤0.001) than those in the highest K+ quartile. This estimation did not change with adjustment for potential confounders. Conversely, participants in the lowest K+ quartile had a 0.14% lower HbA1c (95% CI - 0.19- 0.10: P≤0.001) compared to those in the highest K+ quartile. Conclusion: This cross sectional analysis demonstrated that lower K+ was associated with greater 2hr-glucose. The data supports the possibility that K+ may influence glucose regulation and further research is warranted.
The research was supported by The National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care – East Midlands (NIHR CLAHRC – EM), the Leicester Clinical Trials Unit and the NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit which is a partnership between University Hospitals of Leicester NHS Trust, Loughborough University and the University of Leicester.
CitationJournal of Diabetes Research Volume 2015 (2015), Article ID 923749, 4 pages
Author affiliation/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine
- VoR (Version of Record)