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Short-term progression of optic disc and macular changes in optic nerve head drusen

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journal contribution
posted on 2023-10-03, 08:39 authored by AV Pilat, FA Proudlock, P Kumar, I Gottlob
Purpose: To quantify in patients with optic nerve head drusen (ONHD)changes after 1-year observation in: (i) optic disc and (ii) macular optical coherence tomography (OCT) parameters and (iii) the effect of age at enrolment in the study. Design: Prospective, cross-sectional observational study using Spectral Domain-OCT (Copernicus; OPTOPOL Technology S.A., Zawiercie, Poland) imaging was carried out in 35 patients with ONHD (age–42.8 ± 19.9 years; males = 15; females = 20) at baseline and after 12 months follow-up. Results: Patients with ONHD had significant thinning of the surface nerve fibre layer in the central (p = 0.03), superior (p = 0.05) and inferior (p = 0.04) areas; mean ppRNFL thinning (p = 0.0 4) and ppRNFL thinning in the nasal segment (p = 0.028). Retinal thinning in the central (p = 0.001), inner (p = 0.01) and outer (p = 0.002) temporal, outer superior (p = 0.03) and inferior (p = 0.02) areas; borderline ganglion cell layer thinning (p = 0.051) and outer nuclear layer (p = 0.03) thinning in the central retina and outer segment layer thinning nasally (p = 0.01) between the first and the second visit in macula. Correlation of the difference in optic disc and macular parameters with the age at enrolment did not reveal any significance. Conclusions: Statistically detectable thinning of the optic nerve and macula structures occurred already after 12 months. The proximity of optic nerve changes to the vascular arcades can possibly be explained by involvement of retinal vessels in the pathophysiology of ONHD.

Funding

Ultra-high resolution optical coherence tomography (UHR-SD OCT) in infants and children: characterisation of normal and abnormal foveal development

Medical Research Council

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The Ulverscroft Foundation

History

Author affiliation

School of Psychology and Vision Science, University of Leicester

Version

  • VoR (Version of Record)

Published in

Eye

Volume

37

Issue

7

Pagination

1496 - 1502

Publisher

Springer Science and Business Media LLC

issn

0950-222X

eissn

1476-5454

Copyright date

2023

Available date

2023-10-03

Spatial coverage

England

Language

eng

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