University of Leicester
Browse

Single-cell recordings in the human medial temporal lobe

Download (2.18 MB)
journal contribution
posted on 2015-10-14, 10:19 authored by Hernan G. Rey, Matias J. Ison, C. Pedreira, A. Valentin, G. Alarcon, R. Selway, M. P. Richardson, R. Quian Quiroga
Recordings from individual neurons in patients who are implanted with depth electrodes for clinical reasons have opened the possibility to narrow down the gap between neurophysiological studies in animals and non-invasive (e.g. functional magnetic resonance imaging, electroencephalogram, magnetoencephalography) investigations in humans. Here we provide a description of the main procedures for electrode implantation and recordings, the experimental paradigms used and the main steps for processing the data. We also present key characteristics of the so-called 'concept cells', neurons in the human medial temporal lobe with selective and invariant responses that represent the meaning of the stimulus, and discuss their proposed role in declarative memory. Finally, we present novel results dealing with the stability of the representation given by these neurons, by studying the effect of stimulus repetition in the strength of the responses. In particular, we show that, after an initial decay, the response strength reaches an asymptotic value after approximately 15 presentations that remains above baseline for the whole duration of the experiment.

History

Citation

Journal of Anatomy, 2015, 227 (4), pp. 394-408

Author affiliation

/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Engineering

Version

  • VoR (Version of Record)

Published in

Journal of Anatomy

issn

0021-8782

eissn

1469-7580

Acceptance date

2014-07-11

Copyright date

2014

Available date

2015-10-14

Publisher version

http://onlinelibrary.wiley.com/doi/10.1111/joa.12228/abstract

Language

en

Usage metrics

    University of Leicester Publications

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC