Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
journal contribution
posted on 2015-11-09, 12:02 authored by María Soler Artigas, Louise V. Wain, Suzanne Miller, Abdul Kader Kheirallah, Jennifer E. Huffman, Ioanna Ntalla, Nick Shrine, Ma'en Obeidat, Holly Trochet, Wendy L. McArdle, Alexessander Couto Alves, Jennie Hui, Jing Hua Zhao, Peter K. Joshi, Alexander Teumer, Eva Albrecht, Medea Imboden, Rajesh Rawal, Lorna M. Lopez, Jonathan Marten, Stefan Enroth, Ida Surakka, Ozren Polasek, Leo-Pekka Lyytikäinen, Raquel Granell, Pirro G. Hysi, Claudia Flexeder, Anubha Mahajan, John Beilby, Yohan Bossé, Corry-Anke Brandsma, Harry Campbell, Christian Gieger, Sven Gläser, Juan R. González, Harald Grallert, Chris J. Hammond, Sarah E. Harris, Anna-Liisa Hartikainen, Caroline Hayward, Markku Heliövaara, John Henderson, Lynne Hocking, Momoko Horikoshi, Nina Hutri-Kähönen, Erik Ingelsson, Åsa Johansson, John P. Kemp, Ivana Kolcic, Ashish Kumar, Lars Lind, Erik Melén, Arthur W. Musk, Pau Navarro, David C. Nickle, Sandosh Padmanabhan, Olli T. Raitakari, Janina S. Ried, Samuli Ripatti, Holger Schulz, Robert A. Scott, Don D. Sin, John M. Starr, Ana Viñuela, Henry Völzke, Sarah H. Wild, Alan F. Wright, Tatijana Zemunik, Deborah L. Jarvis, Tim D. Spector, David M. Evans, Terho Lehtimäki, Veronique Vitart, Mika Kähönen, Ulf Gyllensten, Igor Rudan, Ian J. Deary, Stefan Karrasch, Nicole M. Probst-Hensch, Joachim Heinrich, Beate Koch, James F. Wilson, Nicholas J. Wareham, Alan L. James, Andrew P. Morris, Marjo-Riitta Jarvelin, Ian Sayers, David P. Strachan, Ian P. Hall, Martin D. Tobin, UK BiLEVE, Generation ScotlandLung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (Phase 1) imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5x10-8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1, AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
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Citation
Nature Communications, 2015, 6:8658Author affiliation
/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Health SciencesVersion
- VoR (Version of Record)
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Nature CommunicationsPublisher
Nature Publishing Groupeissn
2041-1723Acceptance date
2015-08-27Copyright date
2015Available date
2017-01-26Publisher DOI
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http://www.nature.com/articles/ncomms9658Language
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