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Sleep duration, obesity and insulin resistance in a multi-ethnic UK population at high risk of diabetes.

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posted on 2018-09-27, 08:48 authored by E. M. Brady, D. H. Bodicoat, A. P. Hall, K. Khunti, T. Yates, C. Edwardson, M. J. Davies
AIMS: Investigating the association between sleep duration, obesity, adipokines and insulin resistance (via Leptin:Adiponectin ratio (LAR)), in those at high risk of type 2 diabetes mellitus (T2DM). METHODS: Adults with impaired glucose regulation (IGR) were included. Fasting bloods for inflammatory biomarkers and glycaemic status, 2-h glucose, anthropometrics, objective physical activity, and self-reported sleep were collected. The average number of hours slept in a 24 h period was categorised as ≤5.5, 6-6.5, 7-7.5, 8-8.5, and ≥9 h. Regression models were fitted with sleep (linear and quadratic) and logistic regression used for IGR and adjusted for age, sex, ethnicity, body mass index, waist circumference and objective physical activity. RESULTS: 2848 participants included (593 with inflammatory marker data). Short sleep and long sleep duration were significantly independently associated with higher body mass index (P < 0.001), body weight (P < 0.01), and waist circumference (P < 0.001). 6-7 h of sleep/24 h is associated with the lowest obesity measures. Fasting insulin and LAR were positively associated with sleep duration. Adiponectin levels were negatively associated with sleep duration. CONCLUSIONS: These results support the evidence of an association between short and long sleep duration and indices of obesity. We demonstrate an independent relationship between long sleep duration and insulin resistance.

Funding

This project was supported by The National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care - Leicestershire, Northamptonshire and Rutland (NIHR CLAHRC – LNR), the University of Leicester Clinical Trials Unit and The NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit which is a partnership between University Hospitals of Leicester NHS Trust, Loughborough University and the University of Leicester. Let’s Prevent Diabetes was funded by an NIHR Programme Grant. Walking Away from Diabetes was supported by funding from NIHR CLAHRC for Leicestershire, Northamptonshire and Rutland.

History

Citation

Diabetes Research and Clinical Practice, 2018, 139, pp. 195-202

Author affiliation

/Organisation/COLLEGE OF LIFE SCIENCES/School of Medicine/Diabetes Research Centre

Version

  • AM (Accepted Manuscript)

Published in

Diabetes Research and Clinical Practice

Publisher

Elsevier for International Diabetes Federation

issn

0168-8227

eissn

1872-8227

Acceptance date

2018-03-02

Copyright date

2018

Available date

2019-03-09

Publisher version

https://www.sciencedirect.com/science/article/pii/S0168822716317107?via=ihub

Notes

The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en

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