Pre-edit Solubility and size of polymer nanoparticles.pdf (1.08 MB)
Solubility and size of polymer nanoparticles
journal contribution
posted on 2019-02-07, 09:45 authored by T Cowen, K Karim, SA PiletskyThe solubility of polymer nanoparticles is a complex phenomenon dependent on solvent–solute and
solute–solute interactions. Contrary to phase separation in standard polymerization reactions, which is a
well established research area, the relationship between the solubility of polymer nanoparticles and the
resulting diameter of the nanoparticles has been largely overlooked. Herein we demonstrate that the
absolute size of polymer nanoparticles can be predicted (and controlled) by varying the relevant parameters of the polymerization conditions that influence the solubility and Flory parameter, χs, p. The position of the spinodal, associated with a given χs, p equivalent and determined with a simple thermodynamic model, allows an absolute value, Δχspinodal, to be applied in predicting polymer dimensions. The hydrodynamic diameter of particles at the primarily observed fraction was found to be dependent on D (nm) = −74Δχspinodal + 367 nm, where Δχspinodal must be positive for successful separation. Variation with total polymer fraction over a limited range can also be observed to follow a trend of approximately D (nm) = 173 ln[(xN)2 10−36/Δχspinodal] − 193 nm, thus giving a more general description of polymerization. We also assert the importance of separating spinodal-character phase separation from binodal-character phase separation in polymer nanoparticle synthesis. To the best of our knowledge this is the first successful
Flory–Huggins based thermodynamic model of polymer nanoparticles, and should provide a useful guide
to predictive design of future nanomaterials
History
Citation
POLYMER CHEMISTRY, 2018, 9 (36), pp. 4566-4573 (8)Author affiliation
/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of ChemistryVersion
- AM (Accepted Manuscript)
Published in
POLYMER CHEMISTRYPublisher
Royal Society of Chemistryissn
1759-9954eissn
1759-9962Acceptance date
2018-08-13Copyright date
2018Available date
2019-08-15Publisher DOI
Publisher version
https://pubs.rsc.org/en/Content/ArticleLanding/2018/PY/C8PY00829A#!divAbstractNotes
The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.Language
enAdministrator link
Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC