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Streptococcus pneumoniae: 'captain of the men of death' and financial burden

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journal contribution
posted on 2023-02-03, 15:41 authored by Hasan Yesilkaya, Marco R Oggioni, Peter W Andrew
Streptococcus pneumoniae may inhabit the upper respiratory tract of humans without causing harm but it also causes diseases with high morbidity and mortality. It has excellent adaptive capabilities thanks to its ability to shuffle its genetic content by acquiring and incorporating DNA from other bacteria and is highly competent for genetic transformation. Sugar sensing, cleavage and transport ensure its fitness and survival in the host, and intracellular survival in macrophages has been linked to virulence. The polysaccharide capsule and toxin pneumolysin are the most important virulence determinants. Polysaccharide-based vaccines provide protection against the serotypes represented in vaccine formulations.

Funding

NIH grants R01 AI139077-01A1 and R01 AI135060-01A1.

History

Citation

Yesilkaya, Hasan, Marco R. Oggioni, and Peter W. Andrew. "Streptococcus pneumoniae:‘captain of the men of death’and financial burden." Microbiology 168, no. 12 (2022): 001275.

Author affiliation

Department of Respiratory Sciences; Department of Genetics

Version

  • VoR (Version of Record)

Published in

MICROBIOLOGY

Volume

168

Issue

12

Publisher

MICROBIOLOGY SOC

issn

1350-0872

eissn

1465-2080

Acceptance date

2022-11-12

Copyright date

2022

Available date

2023-02-03

Language

English

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