2022 Yesilkaya mic.pdf (528.85 kB)
Streptococcus pneumoniae: 'captain of the men of death' and financial burden
journal contributionposted on 2023-02-03, 15:41 authored by Hasan Yesilkaya, Marco R Oggioni, Peter W Andrew
Streptococcus pneumoniae may inhabit the upper respiratory tract of humans without causing harm but it also causes diseases with high morbidity and mortality. It has excellent adaptive capabilities thanks to its ability to shuffle its genetic content by acquiring and incorporating DNA from other bacteria and is highly competent for genetic transformation. Sugar sensing, cleavage and transport ensure its fitness and survival in the host, and intracellular survival in macrophages has been linked to virulence. The polysaccharide capsule and toxin pneumolysin are the most important virulence determinants. Polysaccharide-based vaccines provide protection against the serotypes represented in vaccine formulations.
NIH grants R01 AI139077-01A1 and R01 AI135060-01A1.
CitationYesilkaya, Hasan, Marco R. Oggioni, and Peter W. Andrew. "Streptococcus pneumoniae:‘captain of the men of death’and financial burden." Microbiology 168, no. 12 (2022): 001275.
Author affiliationDepartment of Respiratory Sciences; Department of Genetics
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