University of Leicester
Browse

Structural investigations of the RNA-binding properties of STAR proteins

Download (454.03 kB)
journal contribution
posted on 2014-08-29, 14:16 authored by Mikael Feracci, Jaelle Foot, Cyril Dominguez
STAR (signal transduction and activation of RNA) proteins are a family of RNA-binding proteins that regulate post-transcriptional gene regulation events at various levels, such as pre-mRNA alternative splicing, RNA export, translation and stability. Most of these proteins are regulated by signalling pathways through post-translational modifications, such as phosphorylation and arginine methylation. These proteins share a highly conserved RNA-binding domain, denoted STAR domain. Structural investigations of this STAR domain in complex with RNA have highlighted how a subset of STAR proteins specifically recognizes its RNA targets. The present review focuses on the structural basis of RNA recognition by this family of proteins.

History

Citation

Biochemical Society Transactions, 2014, 42 (4), pp. 1141-1146

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Biological Sciences/Department of Biochemistry

Version

  • AM (Accepted Manuscript)

Published in

Biochemical Society Transactions

Publisher

Portland Press

issn

0300-5127

eissn

1470-8752

Copyright date

2014

Available date

2015-02-01

Publisher version

http://www.biochemsoctrans.org/content/42/4/1141

Notes

The final version of record is available at http://www.biochemsoctrans.org/content/42/4/1141

Language

en

Usage metrics

    University of Leicester Publications

    Categories

    No categories selected

    Keywords

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC