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Surgical or Percutaneous Coronary Revascularisation for Heart Failure: An In Silico Model using Routinely Collected Health Data to Emulate a Clinical Trial.

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posted on 2023-10-12, 09:39 authored by Suraj Pathak, Florence Y Lai, Joanne Miksza, Mark C Petrie, Marius Roman, Sarah Murray, Jeremy Dearling, Divaka Perera, Gavin J Murphy

The choice of revascularization with coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI) in people with ischaemic left ventricular dysfunction is not guided by high-quality evidence. Methods A trial of CABG versus PCI in people with heart failure was modelled in-silico using routinely collected healthcare data. The in-silico trial cohort was selected by matching the target trial cohort, identified from Hospital Episode Statistics in England, with individual patient data from the STICH trial. Allocation to CABG versus complex PCI demonstrated random variation across administrative regions in England and was a valid statistical instrument. The primary outcome was 5-year all-cause mortality or cardiovascular hospitalization. Instrumental variable analysis (IVA) was used for the primary analysis. Results were expressed as average treatment effects (ATEs) with 95% confidence intervals (CI).  The target population included 13,519 heart failure patients undergoing CABG or complex PCI between April 2009 and March 2015. After matching, the emulated trial cohort included 2046 patients. The unadjusted primary outcome rate was 51.1% in the CABG group and 70.0% in the PCI group. IVA of the emulated cohort showed that CABG was associated with a lower risk of the primary outcome (ATE -16.2%, 95% CI -20.6% to -11.8%), with comparable estimates in the unmatched target population (ATE -15.5%, 95% CI -17.5% to -13.5%). In people with heart failure, in-silico modelling suggests that CABG is associated with fewer deaths or cardiovascular hospitalizations at 5 years versus complex PCI. A pragmatic clinical trial is needed to test this hypothesis and this trial would be feasible.

Funding

Leicester NIHR Biomedical Research Centre, British Heart Foundation CH/12/1/29419, AA18/3/34220.

History

Citation

European Heart Journal (2023) 44, 351–364

Author affiliation

Cardiovascular Research Centre

Version

  • VoR (Version of Record)

Published in

European Heart Journal

Volume

44

Issue

5

Pagination

351–364

Publisher

Oxford University Press (OUP)

issn

0195-668X

eissn

1522-9645

Acceptance date

2022-11-04

Copyright date

2022

Available date

2023-10-12

Language

en

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