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Survival in South Asian and white European patients after acute myocardial infarction; a UK historical cohort study.

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posted on 2017-07-14, 12:45 authored by Nitin N. Gholap, Kamlesh Khunti, Melanie J. Davies, Danielle H . Bodicoat, Iain B. Squire
Objective To examine the association between ethnicity and survival following acute myocardial infarction (AMI) in White European (WE) and South Asian (SA) patients from a multiethnic UK population. Methods Retrospective, cohort study of 4111 (N=730, 17.8% of SA ethnicity) hospitalised patients, with AMI from a tertiary coronary care centre in the UK, admitted between October 2002 and September 2008. The primary end point was all-cause mortality. The association of ethnicity with survival post AMI was assessed using the Cox regression analysis. Results Compared with WE patients, SA patients were on average younger (62.0 years vs 67.3 years) and had higher prevalence of cardiovascular risk factors including diabetes (39.7% vs 16.1%). During follow-up (median 912, range 1–2556, days), crude mortality rate was 22.6% in SA patients and 26.0% in WE patients (p=0.061). SA ethnicity did not show univariate (HR 0.85 (0.72 to 1.01)) or multivariate (HR, 1.12 (0.94 to 1.34)) association with mortality. Findings were similar for mortality during 0–30 days (1.30 (0.99 to 1.70)), >30 days−1 year (0.97 (0.67 to 1.40)), >1 year–3 years (1.21 (0.83 to 1.76)), >3 years (0.82 (0.47 to 1.41)), and for long-term mortality in survivors from 30 days (1.02 (0.81 to 1.29)). Conclusions When adjusted for differing prevalence of cardiovascular risk factors in the two ethnic groups, survival following AMI was similar for SA and WE patients in the UK.

Funding

This work was supported by the following institutes: The Leicester National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit; the National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care—East Midlands (NIHR CLAHRC—EM), the Leicester Clinical Trials Unit and the NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, which is a partnership between University Hospitals of Leicester NHS Trust, Loughborough University and the University of Leicester.

History

Citation

Heart, 2015, 101, pp. 630-630 (636)

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Cardiovascular Sciences

Version

  • AO (Author's Original)

Published in

Heart

Publisher

BMJ Publishing Group with British Cardiovascular Society

issn

1355-6037

eissn

1468-201X

Acceptance date

2014-10-01

Copyright date

2015

Available date

2017-07-14

Publisher version

http://heart.bmj.com/content/101/8/630

Notes

Pre-print archived as submitting author does not have author accepted manuscript available.

Language

en

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