University of Leicester
Nucl. Acids Res.-2011-Shao-D606-11.pdf (4.3 MB)

TADB: a web-based resource for Type 2 toxin-antitoxin loci in bacteria and archaea.

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journal contribution
posted on 2012-10-24, 08:59 authored by Y. Shao, E. M. Harrison, D. Bi, C. Tai, X. He, H. Y. Ou, K. Rajakumar, Z. Deng
TADB ( is an integrated database that provides comprehensive information about Type 2 toxin-antitoxin (TA) loci, genetic features that are richly distributed throughout bacterial and archaeal genomes. Two-gene and much less frequently three-gene Type 2 TA loci code for cognate partners that have been hypothesized or demonstrated to play key roles in stress response, bacterial physiology and stabilization of horizontally acquired genetic elements. TADB offers a unique compilation of both predicted and experimentally supported Type 2 TA loci-relevant data and currently contains 10,753 Type 2 TA gene pairs identified within 1240 prokaryotic genomes, and details of over 240 directly relevant scientific publications. A broad range of similarity search, sequence alignment, genome context browser and phylogenetic tools are readily accessible via TADB. We propose that TADB will facilitate efficient, multi-disciplinary and innovative exploration of the bacteria and archaea Type 2 TA space, better defining presently recognized TA-related phenomena and potentially even leading to yet-to-be envisaged frontiers. The TADB database, envisaged as a one-stop shop for Type 2 TA-related research, will be maintained, updated and improved regularly to ensure its ongoing maximum utility to the research community.



Nucleic Acids Research, 2011, 39 (Database issue), pp. D606-D611


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