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Talin Dependent Mechanosensitivity of Cell Focal Adhesions

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journal contribution
posted on 2016-03-16, 10:07 authored by Jie Yan, Mingxi Yao, Benjamin T. Goult, Michael P. Sheetz
A fundamental question in mechanobiology is how mechanical stimuli are sensed by mechanosensing proteins and converted into signals that direct cells to adapt to the external environment. A key function of cell adhesion to the extracellular matrix (ECM) is to transduce mechanical forces between cells and their extracellular environment. Talin, a cytoplasmic adapter essential for integrin-mediated adhesion to the ECM, links the actin cytoskeleton to integrin at the plasma membrane. Here, we review recent progress in the understanding of talin-dependent mechanosensing revealed by stretching single talin molecules. Rapid progress in single-molecule force manipulation technologies has made it possible to directly study the impact of mechanical force on talin’s conformations and its interactions with other signaling proteins. We also provide our views on how findings from such studies may bring new insights into understanding the principles of mechanobiology on a broader scale, and how such fundamental knowledge may be harnessed for mechanopharmacology.

History

Citation

Cellular and Molecular Bioengineering, 2014, 8(1), pp. 151-159

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Old Departments Pre 01 Aug 2015/Department of Biochemistry (Pre 01 Aug 2015)

Version

  • VoR (Version of Record)

Published in

Cellular and Molecular Bioengineering

Publisher

Springer US

issn

1865-5025

eissn

1865-5033

Acceptance date

2014-10-25

Copyright date

2014

Available date

2016-03-16

Publisher version

http://link.springer.com/article/10.1007/s12195-014-0364-5

Language

en

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