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Telomere maintenance in soft tissue sarcomas.pdf (653.49 kB)

Telomere maintenance in soft tissue sarcomas.

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posted on 2018-01-11, 12:55 authored by Nicholas Eastley, Barbara Ottolini, Carmen Garrido, Jacqueline A. Shaw, Thomas A. McCulloch, Robert U. Ashford, Nicola J. Royle
Soft tissue sarcomas (STS) are a diverse group of heterogeneous malignant tumours derived from mesenchymal tissues. Over 50 different STS subtypes are recognised by WHO, which show a wide range of different biological behaviours and prognoses. At present, clinicians managing this complex group of tumours face several challenges. This is reflected by the relatively poor outcome of patients with STSs compared with many other solid malignant tumours. These include difficulties securing accurate diagnoses, a lack of effective systemic treatments and absence of any sensitive circulating biomarkers to monitor patients throughout their treatment and follow-up. In order to progress STS's cells must evade the usual cellular proliferative checkpoints, and then activate a telomere maintenance mechanism in order to achieve replicative immortality. The purpose of this review is to provide an overview of STS genetics focusing particularly on these mechanisms. We will also highlight some of the key barriers to improving outcome for patients with STS, and hypothesise how a better understanding of these genetic characteristics may impact on future STS management.

History

Citation

Journal of Clinical Pathology, 2017, 70 (5), pp. 371-377

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/MBSP Non-Medical Departments/Department of Genetics

Version

  • VoR (Version of Record)

Published in

Journal of Clinical Pathology

Publisher

BMJ Publishing Group

issn

0021-9746

eissn

1472-4146

Acceptance date

2016-12-15

Copyright date

2017

Available date

2018-01-11

Publisher version

http://jcp.bmj.com/content/70/5/371

Language

en

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