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Spycher B 2017 Temporal stability of ultiple trigger and episodic viral wheeze in early childhood.pdf (528.64 kB)

Temporal stability of multiple trigger and episodic viral wheeze in early childhood

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posted on 2017-09-12, 15:33 authored by Ben D. Spycher, Cara Cochrane, Raquel Granell, Jonathan A. C. Sterne, Michael Silverman, Eva Pederson, Erol A. Gaillard, John Henderson, Claudia E. Kuehni
The distinction between episodic viral wheeze (EVW) and multiple trigger wheeze (MTW) is used to guide management of preschool wheeze. It has been questioned whether these phenotypes are stable over time. We examined the temporal stability of MTW and EVW in two large population-based cohorts. We classified children from the Avon Longitudinal Study on Parents and Children (N=10,970) and the Leicester Respiratory Cohorts (LRC, N=3,263) into EVW, MTW and no wheeze at ages 2, 4 and 6 years based on parent-reported symptoms. Using multinomial regression, we estimated relative risk ratios (RRRs) for EVW and MTW at follow-up (no wheeze as reference category) with and without adjusting for wheeze severity. Although large proportions of children with EVW and MTW became asymptomatic, those that continued to wheeze showed a tendency to remain in the same phenotype: Among children with MTW at 4 years in LRC the adjusted RRR was 15.6 (95% CI: 8.3, 29.2) for MTW (stable phenotype) compared to 7.0 (2.6, 18.9) for EVW (phenotype switching) at 6 years. The tendency to track was weaker for EVW and from 2-4 years. Results were similar across cohorts. This suggests that MTW and, to a lesser extent, EVW track regardless of wheeze severity.

History

Citation

European Respiratory Journal, 2017, 50: 1700014

Author affiliation

/Organisation/COLLEGE OF MEDICINE, BIOLOGICAL SCIENCES AND PSYCHOLOGY/School of Medicine/Department of Infection, Immunity and Inflammation

Version

  • AM (Accepted Manuscript)

Published in

European Respiratory Journal

Publisher

European Respiratory Society

issn

0903-1936

eissn

1399-3003

Acceptance date

2017-07-31

Copyright date

2017

Available date

2019-05-02

Publisher version

http://erj.ersjournals.com/content/50/5/1700014.article-info

Notes

The file associated with this record is under embargo until 18 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.

Language

en

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