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The Cancer Stem Cell Potency of Group 10‐Azadiphosphine Metal Complexes.pdf (1003.83 kB)

The Cancer Stem Cell Potency of Group 10-Azadiphosphine Metal Complexes

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journal contribution
posted on 2023-02-17, 11:36 authored by Zhiyin Xiao, Joshua Northcote-Smith, Alice Johnson, Kuldip Singh, Kogularamanan Suntharalingam
The cancer stem cell (CSC) potency of a series of structurally analogous Group 10-azadiphosphine metal complexes is reported. The complexes comprise a Group 10 metal (Ni for 1, Pd for 2, or Pt for 3), an azadiphosphine ligand, and two chloride ligands. The complexes exhibit micromolar potency towards bulk breast cancer cells and breast CSCs cultured in monolayer systems. The cytotoxicity of the complexes is comparable to or better than clinically used metallopharmaceuticals, cisplatin and carboplatin, and the gold-standard anti-breast CSC agent, salinomycin. Notably, the breast CSC mammosphere inhibitory effect and potency of the complexes is dependent on the Group 10 metal present, increasing in the following order: 3<2<1. This study highlights the importance of the metal within a given series of structurally related compounds to their breast CSC mammosphere activity and reinforces the therapeutic potential of Group 10 coordination complexes as anti-CSC agents.

Funding

K.S. is supported by an EPSRC New Investigator Award (EP/ S005544/1). Z.X. thanks the National Natural Science Foundation of China (21807047).

History

Citation

Z. Xiao, J. Northcote-Smith, A. Johnson, K. Singh, K. Suntharalingam, Eur. J. Inorg. Chem. 2022, e202200427.

Author affiliation

School of Chemistry

Version

  • VoR (Version of Record)

Published in

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Volume

2022

Issue

32

Pagination

e202200427

Publisher

WILEY-V C H VERLAG GMBH

issn

1434-1948

eissn

1099-0682

Acceptance date

2022-08-03

Copyright date

2022

Available date

2023-02-17

Language

English

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