The Controversies and Difficulties of Diagnosing Primary Ciliary Dyskinesia

<p>We welcome the correspondence from Lavie and Amirav (<a href="https://www.atsjournals.org/doi/full/10.1164/rccm.201907-1334LE#">1</a>), highlighting the difficulties diagnosing primary ciliary dyskinesia (PCD) and the role of high-speed video analysis (HSVA). As members of the European Respiratory Society (ERS) PCD Diagnostic Task Force (<a href="https://www.atsjournals.org/doi/full/10.1164/rccm.201907-1334LE#">2</a>) and/or large PCD Centres, we agree that HSVA has an important role that is not recognized by the American Thoracic Society (ATS) PCD Diagnostic Guideline (<a href="https://www.atsjournals.org/doi/full/10.1164/rccm.201907-1334LE#">3</a>). This risks a large proportion of false-negative “missed” diagnoses and a sizable number of false-positive cases; we make additional important observations.</p><div><br></div>